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浅谈动态观察柴胡皂苷a对实验性癫痫小鼠痫性发作的影响

2017-06-27 14:53:00

广大朋友们,关于“浅谈动态观察柴胡皂苷a对实验性癫痫小鼠痫性发作的影响”是由精品学习网365体育投注体育投注_365体育投注78365.com_365体育投注官方吧频道小编特别编辑整理的,相信对需要各式各样的365体育投注体育投注_365体育投注78365.com_365体育投注官方吧朋友有一定的帮助!

Abstract:?Objective?To?study?the?dynamic?variations?of?the?effect?of?saikosaponin?a?(SSa)?on?epileptic?mice?induced?by?pentylenetetrazol(PTZ),and?to?understand?the?effect?characteristics?of?SSa.?Method?With?the?epileptic?mice?induced?by?PTZ?as?animal?model.?In?the?different?time?point,the?tentative?seizure?incubation?period?and?the?case?of?tetanic?convulsion?were?recorded?to?study?the?characteristics?of?the?antiepileptic?effect?of?SSa?on?mouse?induced?by?PTZ.?Results?In?the?group?of?30min,60?min?and?90?min,the?incubation?period?of?clonic?cramp?was?significantly?prolonged?by?SSa?(P0.05),and?in?the?group?of?90?min,the?effect?was?remarkable?(P0.01).?Also,intraperitoneal?injection?of?SSa?could?prolong?the?incubation?period?of?tetanic?convulsion?in?the?group?of?60?min,90?min?and?120?min?(P0.05).The?effect?was?especially?evident?in?the?group?of?90?min?(P0.01).?In?the?group?of?90?min,the?transition?time?was?remarkably?prolonged?by?SSa?(P0.05).?In?the?group?of?SSa?30?min?and?SSa?60?min,SSa?could?reduce?the?tetanic?convulsion?of?epileptic?mice?introduced?by?PTZ?(P0.05),and?the?effect?is?more?significant?in?the?group?of?60min?than?that?in?the?group?of?30min.?In?the?group?of?30?min?and?60?min,SSa?could?protect?the?epileptic?mice?introduced?by?PTZ?from?tetanic?convulsion?more?significantly?than?those?in?the?group?of?90?min?and?120?min.Conclusions?SSa?can?inhibit?the?epileptic?mice?induced?by?PTZ,SSa?can?protect?the?mouse?from?tetanic?convulsion,and?in?2?hours,the?effect?was?more?remarkable?at?60th?min,90th?min?than?others.

  Key?words:?epilepsy;?Saikosaponin?a;?PTZ;?mice

  柴胡皂苷(saikosaponin)为中药柴胡的主要成分之一,其单体成分之一的柴胡皂苷a(SSa)有降血脂、抗渗出、抗肉芽肿和保护肝细胞等作用[1],对于慢性肾病的治疗也有较好疗效[2,3],但目前尚没有SSa抗癫痫作用的报道。不过已有不少证据表明柴胡及柴胡总皂苷具有镇静和抗实验性癫痫的作用[4,5]。在柴胡皂苷单体各成分中,为明确何种皂苷单体具有抗癫痫作用,笔者研究了SSa对PTZ致痫小鼠痫性发作的影响,并探讨SSa对痫性发作影响的不同时间的动态变化,以期了解SSa抗癫痫药效作用的时间特点。

  1?材?料

  1.1?动物

  健康昆明种小鼠180只,雌雄各半,体质量(20±2)g,由南方医科大学动物实验中心提供,合格证号为2004A063。

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